Exportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 is a second-generation inhibitor of XPO1, demonstrating the lowest level of side effects, and is currently in clinical trials for the treatment of cancers. Previous studies suggest that several first-generation inhibitors of XPO1 demonstrate anti-inflammation activities ...Nov 23, 2018 · Gasdermin D (GSDMD) is a pore-forming protein that induces pyroptosis, a necrotic form of cell death that is initiated after inflammasome activation (1–3).The detection of pathogen- or host-derived danger signals by inflammasomes triggers the activation of inflammatory caspases (caspase-1 and -11 in mice and caspase-1 and -4 in humans), which cleave GSDMD to release autoinhibition on its N ... GSDMD rings form a pore in the plasma membrane that ultimately cause cell lysis. This cell death process (pyroptosis) is a highly inflammatory event, and provides a mechanism of IL-1 release ( Kayagaki et al., 2015; Shi et al., 2015 ). Pyroptosis is not the only means by which IL-1 is released from cells.Aug 14, 2023 · Our basic PHP website is going to feature a home page, including biographical information and some images. For this simple PHP website, you're going to create a single PHP page populated by content from three HTML pages. The index.php file you create can then be edited by adjusting the words and images from the original HTML files. Enter your user name and password, then click Log in. User name: Help Password: Log in Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly ...Nov 12, 2021 · Nerve injury induces profound and complex changes at molecular and cellular levels, leading to axonal self-destruction as well as immune and inflammatory responses that may further promote neurodegeneration. To better understand how neural injury changes the proteome within the injured nerve, we set … Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines ...PMID: 35910382. PMCID: PMC9332914. DOI: 10.3389/fphar.2022.938391. Background: Diabetic nephropathy (DN) is one of the leading causes of chronic kidney disease (CKD) worldwide, tubular injury is the driving force during the pathogenesis and progression of DN. Thus, we aim to utilize the connectivity map (CMap) with renal tubulointerstitial ...PHP is a server scripting language, and a powerful tool for making dynamic and interactive Web pages. PHP is a widely-used, free, and efficient alternative to competitors such as Microsoft's ASP. Start learning PHP now ».How students will get enrolled themselves into a course. This screen capture will guide students to get enrolled into the course themself The advent of deep sequencing technologies has provided us with an unprecedented view of the human genome. Over 85 % of the genome is actively transcribed, yet we do not know the function of the vast majority of these RNA transcripts. Long noncoding RNAs (lncRNA)...邵峰组重磅牛文：神秘蛋白 GSDMD如何“玩转”细胞焦亡. 小编在前期介绍了炎性caspases-1介导的细胞焦亡，这期小编将要深入介绍炎性caspases介导的细胞焦亡的关键底物蛋白GSDMD。. 该底物蛋白是细胞发生焦亡的充要条件。. 该文章是邵峰课题组发表在Nature上的大作 ... Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine the preventive effects of norbergenin, a constituent of traditional anti-inflammatory recipes, on LPS-induced proinflammatory signaling in macrophages and ...Oct 29, 2015 · Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis. Despite the crucial role in immunity … NLRP3 inflammasome activation requires the interaction of NLRP3 with centrosomal kinase NEK7. Here we show that the centrosome-localized deubiquitinase complex Spata2-CYLD deubiquitinates centrosomal kinase PLK4 to augment its binding to and phosphorylation of NEK7, leading to reduced NEK7-NLRP3 interaction and NLRP3 inflammasome activation.PHP is a recursive acronym for "PHP: Hypertext Preprocessor". PHP is a server side scripting language that is embedded in HTML. It is used to manage dynamic content, databases, session tracking, even build entire e-commerce sites. It is integrated with a number of popular databases, including MySQL, PostgreSQL, Oracle, Sybase, Informix, and ...Exportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 is a second-generation inhibitor of XPO1, demonstrating the lowest level of side effects, and is currently in clinical trials for the treatment of cancers. Previous studies suggest that several first-generation inhibitors of XPO1 demonstrate anti-inflammation activities ...Enter your user name and password, then click Log in. User name: Help Password: Log inNerve injury induces profound and complex changes at molecular and cellular levels, leading to axonal self-destruction as well as immune and inflammatory responses that may further promote neurodegeneration. To better understand how neural injury changes the proteome within the injured nerve, we set up a mouse model of sciatic nerve injury (SNI) and conducted an unbiased, quantitative ... Nov 23, 2018 · Gasdermin D (GSDMD) is a pore-forming protein that induces pyroptosis, a necrotic form of cell death that is initiated after inflammasome activation (1–3).The detection of pathogen- or host-derived danger signals by inflammasomes triggers the activation of inflammatory caspases (caspase-1 and -11 in mice and caspase-1 and -4 in humans), which cleave GSDMD to release autoinhibition on its N ... Magupalli et al. report that for NLRP3- and pyrin-mediated inflammasomes, their assembly and downstream functions occur at the microtubule-organizing center (MTOC). This process requires the dynein adaptor HDAC6, which is also a central player in aggresome formation and autophagosomal degradation at the MTOC.Enter your user name and password, then click Log in. User name: Help Password: Log inThere are two main ways to install PHP on a Windows®-based computer: download the Windows Installer or use the Windows Zip file from the PHP Web site. Either method will get PHP working, but both have some extra steps that are needed to make PHP work well. Windows InstallerApr 4, 2019 · The signaling organelles of the innate immune system consist of oligomeric protein complexes known as supramolecular organizing centers (SMOCs). Examples of SMOCs include myddosomes and inflammasomes, which respectively induce transcription-dependent and -independent inflammatory responses. The common use of oligomeric structures as signaling ... IMMUNOLOGY ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation Sebastian Rühl1,2, Kateryna Shkarina 3*, Benjamin Demarco3*, Rosalie Heilig *,Download scientific diagram | Generation of monoclonal iBMDM cells by single-cell cloning. iBMDMs at a concentration of 1 × 10 6 cell per mL are diluted 1:1000 and then 1:100 to obtain a ... Enter your user name and password, then click Log in. User name: Help Password: Log inThe two most prominent members of the interleukin-1 (IL-1) superfamily, IL-1α and IL-1β, are equally potent master inflammatory cytokines that bind to the same receptor, and their deregulated signaling leads to severe acute or chronic inflammation ().PHP is a server scripting language, and a powerful tool for making dynamic and interactive Web pages. PHP is a widely-used, free, and efficient alternative to competitors such as Microsoft's ASP. Start learning PHP now ». NLRP3 inflammasome is a crucial regulator of pro-inflammatory cytokines (IL-1β and IL-18) production through activating caspase-1. Non-coding RNAs (ncRNAs) are a class of RNA transcripts lacking the ability to encode peptides or proteins. Its dysregulation leads to the development and progression of inflammation in diseases.1 Introduction. Inflammasome activation in different tissues is known to be associated with several chronic and acute inflammatory diseases. [1, 2] This form of innate immune response involves the assembly of three major proteins popularly known as the sensor, adaptor, and inactive enzyme, into a multimeric protein complex, which subsequently results in proximity-induced activation of the ...Sep 19, 2018 · Knowledge of the mechanisms regulating formation of the NLRP3 inflammasome is incomplete. Here we report Cl − channel-dependent formation of dynamic ASC oligomers and inflammasome specks that remain inactive in the absence of K + efflux. Formed after Cl − efflux exclusively, ASC specks are NLRP3 dependent, reversible, and inactive, although ... mysqli::query — Performs a query on the database. mysqli::real_connect — Opens a connection to a mysql server. mysqli::real_escape_string — Escapes special characters in a string for use in an SQL statement, taking into account the current charset of the connection. mysqli::real_query — Execute an SQL query.As the seminal step in gluconeogenesis, pyruvate carboxylase (PCB) plays a dominant role in controlling gluconeogenesis. 3 Although the correlation between tumor prosperity and the canonical ...www.php.net – PHP distribution, tutorials, newsgroups, and more. www.phpfreaks.com - PHP and MySQL tutorials, scripts, forums, and more. www.phpbuilder.com – Collection of PHP resources. Hello World If your web server supports PHP, type this example into a text file called hello.php and access it in your browser by30-2005 ™. Iscove's Modified Dulbecco's Medium (IMDM) contains 4 mM L-glutamine, 4500 mg/L glucose, and 1500 mg/L sodium bicarbonate. It has applications for cell culture, cell growth, and viability. Product category. Media.PHP Conditional Statements. Very often when you write code, you want to perform different actions for different conditions. You can use conditional statements in your code to do this. In PHP we have the following conditional statements: if statement - executes some code if one condition is true The user friendly PHP online compiler that allows you to Write PHP code and run it online. The PHP text editor also supports taking input from the user and standard libraries.PHP is a server scripting language, and a powerful tool for making dynamic and interactive Web pages. PHP is a widely-used, free, and efficient alternative to competitors such as Microsoft's ASP. Start learning PHP now ».1. INTRODUCTION. Alzheimer's disease (AD), the most common type of neurodegenerative disease, is characterized by amyloid plaque, neurofibrillary tau tangles, and neuroinflammation, with the latter playing a crucial role in the progression of neuropathological hallmarks of AD (Heneka et al., 2015).Dec 21, 2011 · I have a project that needs to access a DLL with PHP. The server is a Windows machine and the Apache server is provided by XAMPP. I read multiple answers on the web like. Use DLL in PHP? php communication with dll? calling dll through php; http://ca.php.net/manual/en/class.com.php; http://ca2.php.net/manual/en/book.w32api.php We treated WT and Mal −/− iBMDMs with the protein synthesis inhibitor-cycloheximide and studied its effect on R848-induced expression of Ifnβ and Irf7 mRNA ( Figure 4 A,B). Cycloheximide ... Feb 2, 2022 · Next, we investigated whether intervening PCB in TAMs could influence tumor progression and anti-tumor immunity. As PCB suppression could be reversed by alleviating hypoxia (Fig. 1d), we treated ... Instagram The interactive shell stores your history which can be accessed using the up and down keys. The history is saved in the ~/.php_history file. The CLI SAPI provides the php.ini settings cli.pager and cli.prompt. The cli.pager setting allows an external program (such as less) to act as a pager for the output instead of being displayed directly on ...Mar 15, 2022 · There are two main ways to install PHP on a Windows®-based computer: download the Windows Installer or use the Windows Zip file from the PHP Web site. Either method will get PHP working, but both have some extra steps that are needed to make PHP work well. Windows Installer Practice is key to mastering coding, and the best way to put your PHP knowledge into practice is by getting practical with code. Use W3Schools Spaces to build, test and deploy code. The code editor lets you write and practice different types of computer languages. It includes PHP, but you can use it for other languages too. A comment in PHP code is a line that is not executed as a part of the program. Its only purpose is to be read by someone who is looking at the code. Comments can be used to: Let others understand your code. Remind yourself of what you did - Most programmers have experienced coming back to their own work a year or two later and having to re ... The user friendly PHP online compiler that allows you to Write PHP code and run it online. The PHP text editor also supports taking input from the user and standard libraries.Aug 1, 2023 · PHP (recursive acronym for PHP: Hypertext Preprocessor) is a widely-used open source general-purpose scripting language that is especially suited for web development and can be embedded into HTML. Introduction. Inflammasomes are a group of multicomponent signaling platforms in the cytoplasm that control inflammatory response and anti-pathogen defense against a wide range of infection and damage signals 1 – 4.PHP is a server scripting language, and a powerful tool for making dynamic and interactive Web pages. PHP is a widely-used, free, and efficient alternative to competitors such as Microsoft's ASP. Start learning PHP now ».Dec 23, 2020 · The two most prominent members of the interleukin-1 (IL-1) superfamily, IL-1α and IL-1β, are equally potent master inflammatory cytokines that bind to the same receptor, and their deregulated signaling leads to severe acute or chronic inflammation (). May 28, 2021 · Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4 (PAD4), the role of the NLRP3 inflammasome in NETosis was not addressed. Here, we establish that under sterile conditions the cannonical ... Aug 1, 2023 · The interactive shell stores your history which can be accessed using the up and down keys. The history is saved in the ~/.php_history file. The CLI SAPI provides the php.ini settings cli.pager and cli.prompt. The cli.pager setting allows an external program (such as less) to act as a pager for the output instead of being displayed directly on ... Exportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 is a second-generation inhibitor of XPO1, demonstrating the lowest level of side effects, and is currently in clinical trials for the treatment of cancers. Previous studies suggest that several first-generation inhibitors of XPO1 demonstrate anti-inflammation activities ...InstagramExportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 is a second-generation inhibitor of XPO1, demonstrating the lowest level of side effects, and is currently in clinical trials for the treatment of cancers. Previous studies suggest that several first-generation inhibitors of XPO1 demonstrate anti-inflammation activities ...Mycobacterium tuberculosis infection causes high rates of morbidity and mortality. Host-directed therapy may enhance the immune response, reduce tissue damage and shorten treatment duration. The ...As the seminal step in gluconeogenesis, pyruvate carboxylase (PCB) plays a dominant role in controlling gluconeogenesis. 3 Although the correlation between tumor prosperity and the canonical ...Nov 25, 2020 · Activation of TLR7 by small imidazoquinoline molecules such as R848 or R837 initiates signaling cascades leading to the activation of transcription factors, such as AP-1, NF-κB, and interferon regulatory factors (IRFs) and afterward to the induction ... Step 1- Create a HTML PHP Login Form. Step 2: Create a CSS Code for Website Design. View More. In today's digital age, the importance of online security cannot be ignored. As a result, creating a login form is an essential feature for any website that requires user authentication. The following is a guide on creating a login form in PHP.Figure 2 . Cell 2019 177384-398.e11DOI: (10.1016/j.cell.2019.01.039) Copyright © 2019 Elsevier Inc. Terms and Conditions. TBK1 Is a Component of the MyddosomePHP (recursive acronym for PHP: Hypertext Preprocessor) is a widely-used open source general-purpose scripting language that is especially suited for web development and can be embedded into HTML.Here are the steps: Fill out the New Account form with your details. An email will be immediately sent to your email address. Read your email, and click on the web link it contains. Your account will be confirmed and you will be logged in. Now, select the course you want to participate in. As the seminal step in gluconeogenesis, pyruvate carboxylase (PCB) plays a dominant role in controlling gluconeogenesis. 3 Although the correlation between tumor prosperity and the canonical ...Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4 (PAD4), the role of the NLRP3 inflammasome in NETosis was not addressed. Here, we establish that under sterile conditions the cannonical ...PHP is a server-side scripting language created in 1995 by Rasmus Lerdorf. PHP is a widely-used open source general-purpose scripting language that is especially suited for web development and can be embedded into HTML. What is PHP used for? As of October 2018, PHP is used on 80% of websites whose server-side language is known. It is typically ...Jun 9, 2023 · This PHP tutorial, whether you’re a beginner or a professional, our tutorial is designed to provide you with in-depth knowledge of the PHP scripting language. With our PHP tutorial, you’ll learn all the important topics, including control statements, functions, arrays, strings, file handling, form handling, regular expressions, date and ... Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis. Despite the crucial role in immunity …Jun 1, 2022 · Exportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 is a second-generation inhibitor of XPO1, demonstrating the lowest level of side effects, and is currently in clinical trials for the treatment of cancers. Previous studies suggest that several first-generation inhibitors of XPO1 demonstrate anti-inflammation activities ... Example Get your own PHP Server. When the user fills out the form above and clicks the submit button, the form data is sent for processing to a PHP file named "welcome.php". The form data is sent with the HTTP POST method. To display the submitted data you could simply echo all the variables. The "welcome.php" looks like this:Here, we show site-specific caspase-4/11 autoprocessing, generating a p10 product, is required and sufficient for cleaving GSDMD and inducing pyroptosis. The p10-form autoprocessed caspase-4/11 binds the GSDMD-C domain with a high affinity. Structural comparison of autoprocessed and unprocessed capase-11 identifies a β sheet induced by the ... Dec 1, 2019 · PHP is a server-side scripting language created in 1995 by Rasmus Lerdorf. PHP is a widely-used open source general-purpose scripting language that is especially suited for web development and can be embedded into HTML. What is PHP used for? As of October 2018, PHP is used on 80% of websites whose server-side language is known. It is typically ... Knowledge of the mechanisms regulating formation of the NLRP3 inflammasome is incomplete. Here we report Cl − channel-dependent formation of dynamic ASC oligomers and inflammasome specks that remain inactive in the absence of K + efflux. Formed after Cl − efflux exclusively, ASC specks are NLRP3 dependent, reversible, and inactive, although ...30-2005 ™. Iscove's Modified Dulbecco's Medium (IMDM) contains 4 mM L-glutamine, 4500 mg/L glucose, and 1500 mg/L sodium bicarbonate. It has applications for cell culture, cell growth, and viability. Product category. Media.Download scientific diagram | Generation of monoclonal iBMDM cells by single-cell cloning. iBMDMs at a concentration of 1 × 10 6 cell per mL are diluted 1:1000 and then 1:100 to obtain a ...Figure 2 . Cell 2019 177384-398.e11DOI: (10.1016/j.cell.2019.01.039) Copyright © 2019 Elsevier Inc. Terms and Conditions. TBK1 Is a Component of the Myddosome MySQL is a database system used on the web. MySQL is a database system that runs on a server. MySQL is ideal for both small and large applications. MySQL is very fast, reliable, and easy to use. MySQL uses standard SQL. MySQL compiles on a number of platforms. MySQL is free to download and use. MySQL is developed, distributed, and supported by ... Nov 25, 2020 · Activation of TLR7 by small imidazoquinoline molecules such as R848 or R837 initiates signaling cascades leading to the activation of transcription factors, such as AP-1, NF-κB, and interferon regulatory factors (IRFs) and afterward to the induction of cytokines and anti-viral Type I IFNs. In general, TLRs mediate these effects by utilizing different intracellular signaling molecules, one of ... 37 The innate immune system is complex and involves a huge number of proteins. Hence, studies into mechanisms of innate immune activation often rely heavily on access to a wide array ofJan 17, 2021 · Nitrosonisoldipine (NTS) is a photodegradation product of the calcium channel inhibitor nisoldipine. Chen et al. identified NTS as a selective inhibitor of inflammatory caspases that blocks both the ... PHP 8.3.0 RC 1 available for testing. Predefined Variables. Predefined Exceptions. Predefined Interfaces and Classes. Predefined Attributes. Supported Protocols and Wrappers. Variable and Type Related Extensions. "MyClass::myFunc () ""OtherClass::myFunc () ". A class constant, class property (static), and class function (static) can all share ...Developing strategies that promote the resolution of vascular inflammation and atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes produced by naive bone marrow-derived macrophages (BMDM-exo) contain anti-inflammatory microRNA-99a/146b/378a that are further increased in exosomes produced by BMDM polarized with IL-4 (BMDM-IL-4-exo).
1 Introduction. Inflammasome activation in different tissues is known to be associated with several chronic and acute inflammatory diseases. [1, 2] This form of innate immune response involves the assembly of three major proteins popularly known as the sensor, adaptor, and inactive enzyme, into a multimeric protein complex, which subsequently results in proximity-induced activation of the .... .search.json
Affiliations 1 Programa de Pós-Graduação Em Farmácia (PPGFar), Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.; 2 Departamento de Análises Clínicas-CCS, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, SC, 88040-970, Brazil. The interactive shell stores your history which can be accessed using the up and down keys. The history is saved in the ~/.php_history file. The CLI SAPI provides the php.ini settings cli.pager and cli.prompt. The cli.pager setting allows an external program (such as less) to act as a pager for the output instead of being displayed directly on ...We treated WT and Mal −/− iBMDMs with the protein synthesis inhibitor-cycloheximide and studied its effect on R848-induced expression of Ifnβ and Irf7 mRNA ( Figure 4 A,B). Cycloheximide ... BEI Resources macrophages Macrophages, supplied by BEI Resources, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more PHP is a server scripting language, and a powerful tool for making dynamic and interactive Web pages. PHP is a widely-used, free, and efficient alternative to competitors such as Microsoft's ASP. Start learning PHP now ». 邵峰组重磅牛文：神秘蛋白 GSDMD如何“玩转”细胞焦亡. 小编在前期介绍了炎性caspases-1介导的细胞焦亡，这期小编将要深入介绍炎性caspases介导的细胞焦亡的关键底物蛋白GSDMD。. 该底物蛋白是细胞发生焦亡的充要条件。. 该文章是邵峰课题组发表在Nature上的大作 ...Background: Diabetic nephropathy (DN) is one of the leading causes of chronic kidney disease (CKD) worldwide, tubular injury is the driving force during the pathogenesis and progression of DN. Thus, we aim to utilize the connectivity map (CMap) with renal tubulointerstitial transcriptomic profiles of biopsy-proven DN to identify novel drugs for treating DN.Methods: We interrogated the CMap ...How students will get enrolled themselves into a course. This screen capture will guide students to get enrolled into the course themselfAffiliations 1 Programa de Pós-Graduação Em Farmácia (PPGFar), Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.; 2 Departamento de Análises Clínicas-CCS, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, Florianópolis, SC, 88040-970, Brazil. Jun 17, 2022 · PHP is a server-side scripting language designed specifically for web development. It is open-source which means it is free to download and use. It is very simple to learn and use. The files have the extension “.php”. Rasmus Lerdorf inspired the first version of PHP and participated in the later versions. It is an interpreted language and ... Apr 4, 2019 · The signaling organelles of the innate immune system consist of oligomeric protein complexes known as supramolecular organizing centers (SMOCs). Examples of SMOCs include myddosomes and inflammasomes, which respectively induce transcription-dependent and -independent inflammatory responses. The common use of oligomeric structures as signaling ... Sep 19, 2018 · Knowledge of the mechanisms regulating formation of the NLRP3 inflammasome is incomplete. Here we report Cl − channel-dependent formation of dynamic ASC oligomers and inflammasome specks that remain inactive in the absence of K + efflux. Formed after Cl − efflux exclusively, ASC specks are NLRP3 dependent, reversible, and inactive, although ... Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine the preventive effects of norbergenin, a constituent of traditional anti-inflammatory recipes, on LPS-induced proinflammatory signaling in macrophages and ...Practice is key to mastering coding, and the best way to put your PHP knowledge into practice is by getting practical with code. Use W3Schools Spaces to build, test and deploy code. The code editor lets you write and practice different types of computer languages. It includes PHP, but you can use it for other languages too..